Virus-Host Interaction Minireview Series: Human Immunodeficiency Virus, Hepatitis C Virus, and Influenza Virus
Samuel CE

J Biol Chem. 2006 Mar 31;281(13):8305-7. Epub 2005 Dec 30.

Viral agents of infectious disease such as human immunodeficiency virus (HIV),2 influenza virus, and hepatitis C virus (HCV) continue to pose daunting public health challenges. Substantial information is known about the multiplication cycles, the means of transmission, and the diseases caused by these three viruses, all of which are human pathogens that possess RNA genomes (1). Efforts to understand their viral multiplication schemes at the molecular level and to elucidate the interactions that occur between viral and cellular gene products that together determine the host's susceptibility to infection and disease have led to significant new insights about HIV, influenza, and HCV viruses. The first two minireviews in this three-part series concern HIV and influenza virus. They focus on the genetic and biochemical aspects of two viral proteins, the Vif protein of HIV (2) and the M2 protein of influenza virus (3), and the functional roles that they play during establishment of productive viral infections. The third minireview focuses on the structure and function of the viral proteins involved in the replication of HCV RNA (4).

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