Update of the drug resistance mutations in HIV-1: December 2009.
Johnson VA, Brun-Vezinet F, Clotet B, Gunthard HF, Kuritzkes DR, Pillay D, Schapiro JM, Richman DD.



This December 2009 version of the International AIDS Society–USA (IAS–USA) drug resistance mutations list updates the figures last published in December 2008 (Johnson VA et al, Top HIV Med, 2008;16:138-145). This update includes 3 new mutations—K65R for stavudine (Hawkins CA et al, JAIDS, 2009;52:228- 234 and Wallis C et al, JAIDS, October 2009; Epub ahead of print) and K101P for efavirenz and nevirapine (Parkin NT et al, Antimicrob Agents Chemother, 2006;50:351-354; Rhee SY et al, Antimicrob Agents Chemother, 2004:48:3122-3126; and Rhee SY et al, Proc Natl Acad Sci USA, 2006;46:17355-17360). In addition, the darunavir I47V mutation and the lopinavir/ritonavir L76V mutation designations were changed to boldface to indicate their recognition as major rather than minor mutations. One mutation, L33F for tipranavir/ritonavir, was changed from a major mutation to that of a minor to reflect recent information.
Also, many of the user notes were substantially revised.

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